Korean J Gastroenterol.  2012 Jan;59(1):44-47. 10.4166/kjg.2012.59.1.44.

A Case of Primary Colon Amyloidosis Presenting as Hematochezia

  • 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. sw-jeon@hanmail.net


Amyloidosis is characterized by a deposition of insoluble fibrils in various organs and tissues. Amyloid deposition, in the gastrointestinal track, provokes a dysfunction of the organ, due to an accumulation of fibrils, and causes a variety of clinical symptoms and endoscopic findings. Primary amyloidosis in the gastrointestinal tract is rarely reported in Korea. We experienced a case of recurrent intestinal bleeding, in a 59-year-old female patient with primary amyloidosis. A colonoscopy revealed the presence of multiple large circular ulcers. In the entire colon, diffuse nodular lesions with edema and bleeding were found. A colonoscopic biopsy established the diagnosis of amyloidosis, to the exclusion of other disease components. We concluded that the patient had localized amyloidosis. Though a definitive therapeutic strategy has not been established for localized gastrointestinal amyloidosis, the patient has been successfully treated with a high-dose of steroids and azathioprine.


Amyloidosis; Gastrointestinal hemorrhage; Colon
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