J Korean Surg Soc.  2010 Jan;78(1):55-57. 10.4174/jkss.2010.78.1.55.

A Patient with Mixed Squamous Cell and Papillary Thyroid Carcinoma

• Kwak JH
• Jang HJ
• Kim JH
• Ahn JH
• Kang KH
• Han MS

• KMID: 1775446
• DOI: http://doi.org/10.4174/jkss.2010.78.1.55

Abstract

Mixed squamous cell carcinoma and papillary carcinoma in the thyroid gland is a very rare malignant tumor. Primary squamous cell carcinoma of the thyroid may develop from squamous metaplasia of the follicular epithelium in a variety of pathologic conditions, such as other differentiated carcinomas of the thyroid. A 70-year-old man presented with a palpable mass on the right side of the thyroid gland. The patient underwent a right lobectomy without neck lymph node dissection. Histopathological findings revealed primary squamous carcinoma mixed papillary thyroid carcinoma. He underwent a completion thyroidectomy and radioactive iodine therapy. Adjuvant radiotherapy and chemotherapy were not performed.

Keyword

Mixed squamous cell carcinoma and papillary carcinoma; Thyroid gland

MeSH Terms

Aged
Carcinoma
Carcinoma, Papillary
Carcinoma, Squamous Cell
Epithelium
Humans
Iodine
Lymph Node Excision
Metaplasia
Neck
Radiotherapy, Adjuvant
Thyroid Gland
Thyroid Neoplasms
Thyroidectomy
Carcinoma
Iodine
Thyroid Neoplasms

Figure

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  Fig. 1 Contrast-enhanced chest CT scan shows hypodense nodule in right thyroid gland (black arrow).

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  Fig. 2 (A) Microphotograph of immunohistochemical stain. The portion of squamous carcinoma was not stained and the portion of papillary carcinoma was stained (Thyroglobulin, x100). (B) Microphotograph of papillary carcinoma and squamous carcinoma. The epithelium shows squamous differention with stratification and keratin pearl formation (H&E, x100).

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