J Korean Med Sci.  2014 Apr;29(4):599-603. 10.3346/jkms.2014.29.4.599.

A Case of IgG4-Related Disease with Bronchial Asthma and Chronic Rhinosinusitis in Korea

Affiliations
  • 1Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr

Abstract

IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.

Keyword

IgG4-Related Disease; Asthma; Bronchitis, Chronic

MeSH Terms

Asthma/complications/*diagnosis
Chronic Disease
Creatinine/blood
Female
Humans
Immunoglobulin G/*blood
Middle Aged
Pancreas/enzymology
Plasma Cells/physiology
Prednisolone/therapeutic use
Republic of Korea
Rhinitis/complications/*diagnosis/drug therapy
Sinusitis/complications/*diagnosis/drug therapy
Submandibular Gland/pathology
Tomography, X-Ray Computed
Creatinine
Immunoglobulin G
Prednisolone
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