Korean J Gastrointest Endosc.  2004 Dec;29(6):495-499.

Effects of Chronic Alcohol Consumption on Midazolam Induced Sedation during Colonoscopy

Affiliations
  • 1Department of Gastroenterology, Eulji University School of Medicine, Nowon Eulji Medical Center, Seoul, Korea. pys1109@eulji.or.kr

Abstract

BACKGROUND/AIMS
It is suggested that patients consuming large amounts of alcohol are difficult to be sedated by midazolam probably due to cross tolerance. We studied to know the adequate administration doses of midazolam in patients with chronic alcohol consumption.
METHODS
Study I; We prospectively studied 117 outpatients presenting for colonoscopy. According to alcohol consumption we divided four groups such as group I: 0 g/day, group II: <10 g/day, group III: 10~40 g/day, group IV: >40 g/day. We initially administered 0.06 mg/kg midazolam and add up to spontaneous eye closure. We measured grade of amnesia, level of consciousness, endoscopist's assessment and VAS scale for pain after recovery. Study II; We measured induction time after 0.08 mg/kg midazolam in 60 patients who drink alcohol.
RESULTS
Additional amount of midazolam was not significantly different between the groups (group I: 0.0145 mg/ kg, group II: 0.0214 mg/kg, group III: 0.0181 mg/kg, group IV: 0.0199 mg/kg). There were no differences of sedation parameters between the groups. However the induction time was prolonged and correlated with alcohol consumption.
CONCLUSIONS
For adequate sedation in patients with chronic alcohol consumption, longer induction time rather than increasing dosage is required.

Keyword

Alcohol; Conscious sedation; Colonoscopy; Midazolam; Induction time

MeSH Terms

Alcohol Drinking*
Amnesia
Colonoscopy*
Conscious Sedation
Consciousness
Humans
Midazolam*
Outpatients
Prospective Studies
Midazolam
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