Korean J Fertil Steril.  2005 Mar;32(1):9-16.

The Effect of Isoflavone Supplementation on Plasma Biochemical Parameters of Women with Polycystic Ovary Syndrome

• Won HJ
• Kang JH
• Lee MJ
• Yoon S
• Park KH
• Cho DJ
• Song CH
• Lee BS

Abstract

OBJECTIVE
This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome.
METHODS
Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS).
RESULTS
After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDLcholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05).
CONCLUSION
Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome.

Keyword

Isoflavone; Polycystic ovary syndrome; Hormone levels; Lipid profiles; Total antioxidant status

MeSH Terms

Cardiovascular Diseases
Cholesterol
Female
Humans
Lipoprotein(a)
Plasma*
Polycystic Ovary Syndrome*
Testosterone
Triglycerides
Cholesterol
Lipoprotein(a)
Testosterone