J Korean Diabetes Assoc.  2003 Jun;27(3):260-271.

Plasma Adiponectin Concentration and Insulin Resistance in Type 2 Diabetes

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Konkuk University, Seoul, Korea.
  • 2Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea.

Abstract

BACKGROUND: Insulin resistance, which implies impairment of insulin signaling in target tissues, is a common cause of type 2 diabetes. Adipose tissue plays an important role in insulin resistance through the dysregulated production and secretion of adipose-derived proteins, including tumor necrosis factor- , plas- minogen activator inhibitor-1, leptin, resistin, angiotensinogen and adiponectin. Adiponectin has been estimated to be a protective adipocytokine against atherosclerosis and to have an anti-inflammatory effect. In this study, the relationship between the fasting plasma adiponectin concentration and the adiposity, body composition, insulin sensitivity (ITT, HOMA(IR), QUICK), lipid profile, fasting insulin concentration were examined in type 2 diabetes. The difference in the adiponectin concentrations of diabetic and non-diabetic subjects were also examined, with adjustment for sex, age and body mass index.
METHODS
One hundred ans two type 2 diabetes and 50 controls were the subjects of this study. After a 12-h overnight fast, all subjects underwent a 75g oral glucose tolerance test. Baseline blood samples were drawn to determine the fasting plasma glucose, insulin, adiponectin, total cholesterol, triglyceride and the LDL- and HDL- cholesterol levels. The body composition was estimated by a bioelectric impedance analyzer (Inbody 2.0(r)) and the insulin sensitivity by an insulin tolerance test (ITT), HOMA(IR) and QUICKI method.
RESULTS
In the diabetic group, the fasting adiponectin concentrations were higher in the women than the men. The fasting adiponectin concentrations were negatively correlated with the BMI (r=-0.453), hip circumference (r=-0.341), fasting glucose concentrations (r=-0.277) and HOMA(IR) (r=-0.233). In addition, they were positively correlated with the systolic blood pressure (r=0.321) and HDL-cholesterol (r=0.291). From a multiple logistic regression analysis the systolic blood pressure and HDL-cholesterol were found to be independent variables that influenced the adiponectin concentration. The adiponectin concentrations were significantly lowered in the diabetic than the non-diabetic group, with the exception of the obese male subjects.
CONCLUSION
The plasma adiponectin concentrations were closely related to the insulin resistance parameters in type 2 diabetic patients.

Keyword

Diabetes Mellitus; Insulin Resistance; Adiponectin

MeSH Terms

Adiponectin*
Adipose Tissue
Adiposity
Angiotensinogen
Atherosclerosis
Blood Glucose
Blood Pressure
Body Composition
Body Mass Index
Cholesterol
Diabetes Mellitus
Electric Impedance
Fasting
Female
Glucose
Glucose Tolerance Test
Hip
Humans
Insulin Resistance*
Insulin*
Leptin
Logistic Models
Male
Necrosis
Plasma*
Resistin
Triglycerides
Adiponectin
Angiotensinogen
Cholesterol
Glucose
Insulin
Leptin
Resistin
Full Text Links
  • JKDA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr