Korean J Anesthesiol.  2008 Sep;55(3):320-325. 10.4097/kjae.2008.55.3.320.

The optimal dosage of alfentanil pretreatment for prevention of myoclonus after injection of etomidate

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Guri Hospital, College of Medicine, Hanyang University, Guri, Korea. goldnan@hanyang.ac.kr

Abstract

BACKGROUND: Myoclonus is a common problem during induction of general anesthesia with etomidate. We investigated the optimal dosage of alfentanil pretreatment for prevention of myoclonus after injection of etomidate.
METHODS
In a double blinded fashion, 76 patients scheduled for outpatient elective surgery were randomized into 4 groups according to pretreatment drug: alfentanil 2.5microgram/kg, alfentanil 5microgram/kg, alfentanil 10microgram/kg, or normal saline. The pretreatment was followed by etomidate 0.3 mg/kg IV. Laryngeal mask airway (LMA) was inserted at 5 minutes after the induction. The patients were observed for any myoclonic movement. Onset time, duration and intensity of myoclonus, side effects of alfentanil, mean arterial pressure and heart rate were measured during the study period.
RESULTS
There were significant differences in the incidence and intensity of myoclonus. An injection of 5, and 10microgram/kg alfentanil before etomidate prevented increase of mean arterial pressure and heart rate after LMA insertion. But injection of 10 microgram/kg alfentanil before etomidate appeared generalized muscle rigidity, bradycardia and hypotension.
CONCLUSIONS
An injection of 2.5, 5, and 10microgram/kg alfentanil before etomidate decreases the incidence and intensity of myoclonus. But injection of 10microgram/kg alfentanil before etomidate appeared side effects. Therefore the optimal dosage of alfentanil pretreatment for prevention of myoclonus after injection of etomidate is 5microgram/kg.

Keyword

alfentanil; etomidate; myoclonus

MeSH Terms

Alfentanil
Anesthesia, General
Arterial Pressure
Bradycardia
Etomidate
Heart Rate
Humans
Incidence
Laryngeal Masks
Muscle Rigidity
Myoclonus
Outpatients
Alfentanil
Etomidate
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