J Prev Med Public Health.  2005 Feb;38(1):101-106.

The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases

Affiliations
  • 1Department of Preventive Medicine and Health Promotion Research Center, College of Medicine, Kyungpook National University, Daegu, Korea. bychun@knu.ac.kr

Abstract


OBJECTIVES
We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases METHODS: We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-cholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. All the patients' GGT levels were within the normal range. RESULTS: After adjustment were made for age, body mass index (BMI), smoking status, drinking frequency, exercise frequency and coffee intake, the serum GGT level was positively associated with fasting blood glucose (p< 0.01), total cholesterol (p< 0.01), and triglyceride (p< 0.01) in men, and it was positively associated with fasting blood glucose (p< 0.01), total cholesterol (p< 0.05), triglyceride (p< 0.01), and uric acid (p< 0.01) in women. The associations were not significantly different depending on the status of alcohol drinking or obesity, except for the associations of serum GGT with diastolic blood pressure (P for interaction=0.04) and uric acid (P for interaction=0.04) between the lean and obese subjects. CONCLUSIONS: Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. These results suggest that GGT has important clinical implications as being more than just a marker of alcohol consumption and hepatobiliary disease.

Keyword

Gamma-glutamyltransferase; Cardiovascular diseases; Drinking; Body mass index

MeSH Terms

Adult
Body Mass Index
Cardiovascular Diseases/*etiology
Cross-Sectional Studies
Female
Humans
Korea
Male
Middle Aged
Risk Factors
gamma-Glutamyltransferase/*analysis/blood
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