Korean J Ophthalmol.  1991 Dec;5(2):59-67. 10.3341/kjo.1991.5.2.59.

Effect of gamma-interferon on fibroblast proliferation and collagen synthesis after glaucoma filtering surgery in white rabbits

• Lee YC
• Park MH
• Baek NH

• KMID: 1735081
• DOI: http://doi.org/10.3341/kjo.1991.5.2.59

Abstract

Failure of a glaucoma filtering operation mainly results from scarring at the filtering wound, and postoperative proliferation and migration of fibroblasts play an important role histologically in the formation of scar tissue. As an inhibitory agent for fibroblast proliferation, gamma-interferon has been introduced, and the application of gamma-interferon following filtering surgery is now being made on a trial basis. We studied the effect of gamma-interferon histologically on the fibroblast proliferation and collagen synthesis occurring at the filtering site by comparing the effect of gamma-interferon on the experimental group with that of 5-fluorouracil on the control group, using 10 rabbits (20 eyes) after posterior lip sclerectomy. Both groups showed similar flat and diffused bleb grossly and also showed a similar inhibitory effect on fibroblast proliferation and collagen fiber synthesis histologically. Our findings seem to justify the clinical use of gamma-interferon. Further studies on adequate dosage, method of administration, and local and systemic complications would be desired.

Keyword

glaucoma filitering surgery; gamma-interferon; fibroblast proliferation; collagen synthesis

MeSH Terms

Animals
Anterior Chamber/drug effects
Cell Division/drug effects
Collagen/*biosynthesis
Fibroblasts/drug effects
Fluorouracil/pharmacology
Glaucoma/pathology/*surgery
Interferon-gamma/*pharmacology
Rabbits
Sclera/pathology
*Sclerostomy
Collagen
Fluorouracil
Interferon-gamma