Brain Tumor Res Treat.  2014 Apr;2(1):36-38. 10.14791/btrt.2014.2.1.36.

Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Review of the Literature

Affiliations
  • 1Department of Neurosurgery, Gil Medical Center, Gachon University, Incheon, Korea. gtyee@gilhospital.com

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.

Keyword

Glioblastoma; Neurofibromatosis type 1; CCRT; Temozolomide

MeSH Terms

Adult
Astrocytoma
Brain Neoplasms
Drug Therapy
Glioblastoma*
Hand
Headache
Humans
Male
Neurofibromatosis 1*
Optic Nerve Glioma
Pathology
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