Chonnam Med J.  2010 Aug;46(2):121-124. 10.4068/cmj.2010.46.2.121.

Sarcomatoid Carcinoma in the Urinary Bladder

Affiliations
  • 1Department of Urology, Kwangju Christian Hospital, Gwangju, Korea. swp153@gmail.com

Abstract

Sarcomatoid carcinoma of the urinary bladder is a rare malignant neoplasm in which the tumor consists of both carcinomatous and sarcomatous elements. In Korea, only 1 case of bladder and renal pelvis primary sarcomatoid carcinoma and 4 cases of carcinosarcoma involving the bladder have been reported. Recently, we experienced a case of sarcomatoid carcinoma of the bladder in a 78-year-old male patient experiencing severe gross hematuria. An ultrasound demonstrated a broad-based tumor 4.5x3.6 cm in size on the lateral side of the right ureteral orifice in the bladder dome. Under the diagnosis of a bladder tumor, transurethral resection of the bladder tumor (TURBT) was performed. A subsequent histological examination of the biopsy specimens showed both malignant mesenchymal and epithelial elements. As a result, the tumor was pathologically confirmed as a primary sarcomatoid carcinoma of the urinary bladder.

Keyword

Urinary bladder; Carcinoma; Carcinosarcoma

MeSH Terms

Aged
Biopsy
Carcinosarcoma
Hematuria
Humans
Kidney Pelvis
Korea
Male
Ureter
Urinary Bladder
Urinary Bladder Neoplasms

Figure

  • Fig. 1 Microscopic findings showing a mixture of carcinomatous and sarcomatous elements. The tumor contains spindle-shaped cells (H&E, ×400).

  • Fig. 2 Immunohistochemical staining for (A) cytokeratin and (B) vimentin (×200). The images reveal the diffuse cytoplasmic positivity in the tumor cells of the sarcomatoid area.

  • Fig. 3 After transurethral resection of the bladder tumor (TURBT), the CT scan shows the irregular thickening of the right lateral wall and perivesical haziness.


Reference

1. Arenas LF, Fontes DA, Pereira EM, Hering FL. Sarcomatoid carcinoma with osseous differentiation in the bladder. Int Braz J Urol. 2006. 32:563–565.
Article
2. Jeong YB, Park JK, Kim HJ, Moon WS. A case of sarcomatoid carcinoma of the bladder. Korean J Urol. 1999. 40:252–255.
3. Fromowitz FB, Bard RH, Koss LG. The epithelial origin of a malignant mesodermal mixed tumor of the bladder: report of cases with long-term survival. J Urol. 1984. 132:978–981.
Article
4. Iezzoni JC, Mills SE. Sarcomatoid carcinomas (carcinosarcomas) of the gastrointestinal tract: a review. Semin Diagn Pathol. 1993. 10:176–187.
5. Guarino M, Tricomi P, Giordano F, Cristofori E. Sarcomatoid carcinomas: pathological and histopathogenetic considerations. Pathology. 1996. 28:298–305.
Article
6. Kang SG, Yoon CY, Cho JH, Yoon DK, Kim IS. Sarcomatoid carcinoma of the renal pelvis. Korean J Urol. 2005. 46:651–654.
7. Norchomoviz LE, Metwalli NE, Gupta P. Silverberg SG, DeLellis RA, Frable WS. The renal pelvis, ureter, urinary bladder, and urethra. Principles and practice of surgical and cytopathology. 1997. 3rd ed. New York: Churchill Livingston;235–285.
8. Lopez-Beltran A, Pacelli A, Rothenberg HJ, Wollan PC, Zincke H, Blute ML, et al. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases. J Urol. 1998. 159:1497–1503.
Article
9. Perret L, Chaubert P, Hessler D, Guillou L. Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature. Cancer. 1998. 82:1535–1549.
Article
10. Nuwahid F, German K, Campbell F, Stephenson T. Carcinosarcoma in a bladder diverticulum. Urology. 1994. 44:775–778.
Full Text Links
  • CMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr