Korean J Pediatr Infect Dis.  2014 Aug;21(2):139-143.

Supraclavicular BCG Lymphadenitis Noted at 21 Months after BCG Vaccination Confirmed by a Molecular Method

Affiliations
  • 1Department of Pediatrics, Graduate School of Medicine, Gachon University, Incheon, Korea. hkcho@gilhospital.com
  • 2Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Bacille Calmette-Guerin (BCG) lymphadenitis is the most common complication of BCG vaccination. It commonly occurs in infants aged <6 months involving ipsilateral axillary lymph nodes. We described BCG lymphadenitis in a 22-month-old boy presenting swelling of left supraclavicular lymph node that was confirmed by real-time polymerase chain reaction (PCR) and the multiplex PCR targeting the region of difference (RD).

Keyword

BCG lymphadenitis; Tokyo strain

MeSH Terms

Humans
Infant
Lymph Nodes
Lymphadenitis*
Male
Multiplex Polymerase Chain Reaction
Mycobacterium bovis*
Real-Time Polymerase Chain Reaction
Vaccination*

Figure

  • Fig. 1. Erythematous, fluctuant and tender mass on left supraclavicular area presented at 21 months after BCG vaccination.


Reference

References

1. Bannon MJ. BCG and tuberculosis. Arch Dis Child. 1999; 80:80–3.
2. Lotte A, Wasz-Hockert O, Poisson N, Engbaek H, Land-mann H, Quast U, et al. Second IUATLD study on complications induced by intradermal BCG-vaccination. Bull Int Union Tuberc Lung Dis. 1988; 63:47–59.
3. Milstien JB, Gibson JJ. Quality control of BCG vaccine by WHO: a review of factors that may influence vaccine effectiveness and safety. Bull World Health Organ. 1990; 68:93–108.
4. Kim SH, Kim SY, Eun BW, Yoo WJ, Park KU, Choi EH, et al. BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method. Vaccine. 2008; 26:4379–81.
Article
5. Mori T, Yamauchi Y, Shiozawa K. Lymph node swelling due to bacille Calmette-Guerin vaccination with multi-puncture method. Tuber Lung Dis. 1996; 77:269–73.
6. Hwang JS, Choi YY, Ma JS, Hwang TJ. A clinical study on BCG lymphadenitis. J Korean Pediatr Soc. 1997; 40:614–9.
7. Teo SS, Smeulders N, Shingadia DV. BCG vaccine-associated suppurative lymphadenitis. Vaccine. 2005; 23:2676–9.
Article
8. Bolger T, O'Connell M, Menon A, Butler K. Complications associated with the bacille Calmette-Guerin vaccination in Ireland. Arch Dis Child. 2006; 91:594–7.
Article
9. Ustvedt HJ. Local reaction in BCG vaccination. Bull World Health Organ. 1950; 2:441–68.
10. Goraya JS, Virdi VS. Bacille Calmette-Guerin lymphadenitis. Postgrad Med J. 2002; 78:327–9.
Article
11. Kim YJ, Park MY, Kim SY, Cho SA, Hwang SH, Kim HH, et al. Evaluation of the performances of AdvanSure TB/NTM real time PCR kit for detection of mycobacteria in respiratory specimens. Korean J Lab Med. 2008; 28:34–8.
Article
12. Jou R, Huang WL, Su WJ. Tokyo-172 BCG vaccination complications, Taiwan. Emerg Infect Dis. 2009; 15:1525–6.
Article
13. Warren RM, Gey van Pittius NC, Barnard M, Hesseling A, Engelke E, de Kock M, et al. Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference. Int J Tuberc Lung Dis. 2006; 10:818–22.
14. Soman S, Joseph BV, Sarojini S, Kumar RA, Katoch VM, Mundayoor S. Presence of region of difference 1 among clinical isolates of Mycobacterium tuberculosis from India. J Clin Microbiol. 2007; 45:3480–1.
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