Korean J Parasitol.  2008 Sep;46(3):195-198. 10.3347/kjp.2008.46.3.195.

High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar

Affiliations
  • 1Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul 122-701, Korea.
  • 2Vector Borne Diseases Control Project, Department of Health, 36 Theinbyu Road, Mandalay, Myanmar.
  • 3Department of Parasitology and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 660-751, Korea.
  • 4Department of Parasitology and Inha Research Institute for Medical Sciences, Inha University College of Medicine, Incheon 400-712, Korea. tongsookim@inha.ac.kr

Abstract

Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.

Keyword

Plasmodium falciparum; liver stage malaria antigen; recombinant proteint; antibody response; Myanmar
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