Korean J Parasitol.  2008 Sep;46(3):175-177. 10.3347/kjp.2008.46.3.175.

Successful Treatment of Lupoid Cutaneous Leishmaniasis with Glucantime and Topical Trichloroacetic Acid (A Case Report)

  • 1Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Sadeghian@sdlrc.mui.ac.ir
  • 2Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
  • 3Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
  • 4Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.


Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.


Leishmanis tropica; cutaneous leishmaniasis; trichloroacetic acid

MeSH Terms

Administration, Topical
Antiprotozoal Agents/administration & dosage/*therapeutic use
Leishmaniasis, Cutaneous/*drug therapy/pathology
Meglumine/*therapeutic use
Organometallic Compounds/*therapeutic use
Trichloroacetic Acid/administration & dosage/*therapeutic use
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