J Vet Sci.  2008 Sep;9(3):241-245. 10.4142/jvs.2008.9.3.241.

Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration

• Raina R
• Prawez S
• Dimitrova
• Pankaj NK
• Verma PK

• KMID: 1718576
• DOI: http://doi.org/10.4142/jvs.2008.9.3.241

Abstract

We evaluated the pharmacokinetics of ciprofloxacin in serum (n = 6) and urine (n = 4) in goats following a single intravenous administration of 4 mg/kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant (beta) and elimination half-life (t(1/2beta)) were 0.446 +/- 0.04 h(-1) and 1.630 +/- 0.17 h, respectively. The apparent volume of distribution at steady state (Vd(ss)) was 2.012 +/- 0.37 l/kg and the total body clearance (Cl(B)) was 16.27 +/- 1.87 ml/min/kg. Urinary recovery of ciprofloxacin was 29.70% +/- 10.34% of the administered dose within 36 h post administration. In vitro serum protein binding was 41% +/- 13.10%. Thus, a single daily intravenous dose of 4 mg/kg is sufficient to maintain effective levels in serum and for 36 h in urine, allowing treatment of systemic, Gram-negative bacterial infections and urinary tract infections by most pathogens.

Keyword

ciprofloxacin; disposition kinetics; goat; urinary excretion

MeSH Terms

Animals
Ciprofloxacin/administration & dosage/*pharmacokinetics/pharmacology/*urine
Goats
Gram-Negative Bacteria/drug effects
Gram-Positive Bacteria/drug effects
Injections, Intravenous
Jugular Veins
Kinetics
Protein Binding

Figure

• 

  Fig. 1 Semi-logarithmic graph depicting the serum concentration-time profile of ciprofloxacin in goat following single intravenous dose of 4 mg/kg body weight (n = 6).

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