Korean J Gastroenterol.  2010 Oct;56(4):236-241. 10.4166/kjg.2010.56.4.236.

Rates of Early Surgery and Associated Risk Factors in Crohn's Disease

• Jeon SJ
• Lee KJ
• Lee MH
• Lim SK
• Kang CJ
• Kim JH

• KMID: 1718359
• DOI: http://doi.org/10.4166/kjg.2010.56.4.236

Abstract

BACKGROUND/AIMS
The individual course of Crohn's disease is diverse, and some patients may require bowel resection. The aims of this study were to determine the early surgery rate of Crohn's disease and to identify risk factors associated with early surgery in Korea.
METHODS
Ninety six patients with Crohn's disease (68 men; median age at the time of diagnosis: 25 years), who had been followed up more than a year, were retrospectively analyzed. Early surgery was defined as a bowel operation for Crohn's disease or its complications occurring within 3 years from diagnosis. Early surgery rate and risk factors for early surgery were identified.
RESULTS
Fifteen patients (15.6%) underwent early surgery. The cumulative surgery rate was 8.6% after 6 months, 11.9% after 12 months, 14.1% after 18 months, and 16.7% after 24 to 36 months. Multivariate analysis revealed penetrating or stricturing behavior to be an independent risk factor for early surgery (p<0.001, Exp (B)=2.97 CI 1.39-6.37).
CONCLUSIONS
The cumulative early surgery rate in Korean patients seems to be lower than Western patients. Penetrating or stricturing behavior is significantly associated with early surgery, requiring early aggressive medical treatments.

Keyword

Crohn's disease; Early surgery; Complications; Stricture

MeSH Terms

Adolescent
Adult
Aged
Constriction, Pathologic
Crohn Disease/*surgery
Female
Humans
Male
Middle Aged
Multivariate Analysis
Republic of Korea
Retrospective Studies
Risk Factors
Sex Factors
Time Factors

Figure

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  Fig. 1. Age distribution of the patients with Crohn's disease at diagnosis. The peak incidence was observed in the 2 nd and 3 rd decades.

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  Fig. 2. Cumulative surgery rates of 96 patients. The cumulative surgery rate at 3 years after diagnosis was 16.7%.

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