Yonsei Med J.  2012 Jul;53(4):701-707. 10.3349/ymj.2012.53.4.701.

The Influence of Diabetes Mellitus on Short-Term Outcomes of Patients with Bleeding Peptic Ulcers

• Murata A
• Matsuda S
• Kuwabara K
• Ichimiya Y
• Fujino Y
• Kubo T

• KMID: 1716866
• DOI: http://doi.org/10.3349/ymj.2012.53.4.701

Abstract

PURPOSE
Little information is available on the influence of diabetes mellitus on the short-term clinical outcomes of patients with bleeding peptic ulcers. The aim of this study is to investigate whether diabetes mellitus influences the short-term clinical outcomes of patients with bleeding peptic ulcers using a Japanese national administrative database.
MATERIALS AND METHODS
A total of 4863 patients treated by endoscopic hemostasis on admission for bleeding peptic ulcers were referred to 586 participating hospitals in Japan. We collected their data to compare the risk-adjusted length of stay (LOS) and in-hospital mortality of patients with and without diabetes mellitus within 30 days. Patients were divided into two groups: patients with diabetes mellitus (n=434) and patients without diabetes mellitus (n=4429).
RESULTS
Mean LOS in patients with diabetes mellitus was significantly longer than those without diabetes mellitus (15.8 days vs. 12.5 days, p<0.001). Also, higher in-hospital mortality within 30 days was observed in patients with diabetes mellitus compared with those without diabetes mellitus (2.7% vs. 1.1%, p=0.004). Multiple linear regression analysis revealed that diabetes mellitus was significantly associated with an increase in risk-adjusted LOS. The standardized coefficient was 0.036 days (p=0.01). Furthermore, the analysis revealed that diabetes mellitus significantly increased the risk of in-hospital mortality within 30 days (odds ratio=2.285, 95% CI=1.161-4.497, p=0.017).
CONCLUSION
This study demonstrated that presence of diabetes mellitus significantly influences the short-term clinical outcomes of patients with bleeding peptic ulcers.

Keyword

Bleeding peptic ulcers; diabetes mellitus; health care quality; retrospective studies; databases

MeSH Terms

Aged
Aged, 80 and over
Diabetes Mellitus/*physiopathology
Female
Hemostasis, Endoscopic
Hospital Mortality
Humans
Japan
Length of Stay/statistics & numerical data
Male
Middle Aged
Peptic Ulcer Hemorrhage/mortality/*pathology
Regression Analysis

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