Korean J Parasitol.  1992 Dec;30(4):277-281. 10.3347/kjp.1992.30.4.277.

Susceptibility of various animals to Pneumocystis carinii infection

Affiliations
  • 1Department of Parasitology, Seoul National University College of Medicine, Korea.

Abstract

Pneumocystis carinii (Pc) is an important opportunistic pathogen of immune compromised hosts, and is known to infect various animals. The present study observed the infection status of 6 mammals and 3 strains of albino rats with Pc after suppression of their immunity. Methyl-prednisolone was injected once a week and tetracycline was supplied with water for 5 to 21 weeks. Hamsters, guinea pigs, rabbits, dogs, cats and pigs were negative by impression smear, and only the rats were found infected by Pc. All of the three strains of rats, Sprague-Dawley(SD), Wistar(W) and Fisher(F), were infected by Pc but W rats showed heavier degree of infection in earlier period than F or SD rats. The present findings suggest that W rat is the best among the animals used in the present study for production of Pc.


MeSH Terms

Cats-
Disease-Susceptibility
Dogs-
Guinea-Pigs
Hamsters-
Immunocompromised-Host
Methylprednisolone-
Pneumocystis-carinii-Infections-parasitology
Rabbits-
Rats-
Rats,-Inbred-F344
Rats,-Sprague-Dawley
Rats,-Wistar
Swine-
*Pneumocystis-carinii-pathogenicity
*Pneumocystis-carinii-Infections-immunology
Methylprednisolone
Full Text Links
  • KJP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr