Korean J Parasitol.  1988 Mar;26(1):27-32. 10.3347/kjp.1988.26.1.27.

Comparative evaluation of indirect immunofluorescent antibody test with enzyme-linked immunosorbent assay in serodiagnosis of human neurocysticercosis

Affiliations
  • 1Department of Parasitology, College of Medicine, Chungbuk National University, Cheongju 360-763, Korea.
  • 2Department of Parasitology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
  • 3Department of Parasitology, College of Medicine, Korea University, Seoul 110-522, Korea.

Abstract

The applicability of indirect immunofluorescent antibody test (IFAT) was compared with enzyme-linked immunosorbent assay (ELISA) in sera from 163 cases of confirmed neurocysticercosis, 101 other neurologic and parasitic diseases and 100 normal controls. As antigen, frozen sections of a Taenia solium metacestode from a human brain was used in IFAT and cystic fluid was used in ELISA. For the detection of specific IgG antibody, IFAT was equally sensitive (89. 6%) and specific (85. l%) as ELISA. The antibody titers by IFAT were correspondingly increased with mean absorbance of ELISA. The corresponding rate of positivity in the two techniques was 90.8%. Except for the difficulty in detecting antibodies in cerebrospinal fluid (CSF), IFAT was concluded to be very useful for the serodiagnosis of human neurocysticercosis.

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