J Korean Med Sci.  2012 Aug;27(8):934-938. 10.3346/jkms.2012.27.8.934.

Influences on Formation of Tetanus Antibody after Simultaneous Injection of Tetanus Immunoglobulin with Tetanus Vaccine

Affiliations
  • 1Department of Emergency Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea. skyshin1@dreamwiz.com
  • 2Department of Emergency Medicine, Gachon University Gill Hospital, Incheon, Korea.

Abstract

The goal of this study was to determine how much the formation of tetanus antibody is influenced after a single injection of tetanus vaccine (Td) and the simultaneous injection of tetanus vaccine with tetanus immunoglobulin (TIG). All of the healthy adult volunteers were divided into two groups: group 1 (Td only) and group 2 (Td plus TIG). Two hundred thirty seven volunteers were enrolled. When the baseline antibody titer, gender and age were adjusted, the geometric mean titers (GMTs) of the tetanus antibody (group 1 vs group 2) was 0.8438 IU/mL vs 0.5684 IU/mL at 4 weeks (P = 0.002), 0.4074 IU/mL vs 0.3217 IU/mL at 6 months (P = 0.072) and 0.3398 IU/mL vs 0.2761 IU/mL at 12 months (P = 0.140) after injection, respectively. The formation of tetanus antibody after tetanus vaccination is not influenced by TIG at the late period and in adults below the age of 50 yr, but there are significant differences between the two groups at the early period of 4 weeks after vaccination and for the patients over 60 yr.

Keyword

Tetanus; Tetanus Toxoid; Immunoglobulins

MeSH Terms

Adult
Age Factors
Antibodies, Bacterial/blood
Female
Humans
Immunoglobulins/*administration & dosage
Male
Middle Aged
Sex Factors
Tetanus/immunology/*prevention & control
Tetanus Toxoid/*administration & dosage/immunology
Time Factors
Antibodies, Bacterial
Immunoglobulins
Tetanus Toxoid

Figure

  • Fig. 1 Comparison of the GMTs between the groups according to time after adjustment of gender and age. GMTs, geometric mean titers.

  • Fig. 2 Changes of the GMTs between the groups according to age after adjustment of gender and time. GMTs, geometric mean titers.


Reference

1. Center for Disease Control. Diphtheria, tetanus and pertussis: recommendations for vaccine use and other preventive measures recommendations of the immunization practices advisory committee (ACIP). MMWR Recomm Rep. 1991. 40:1–28.
2. Talan DA, Abrahamian FM, Moran GJ, Mower WR, Alagappan K, Tiffany BR, Pollack CV, Steele MT, Dunbar LM, Bajani MD, et al. Tetanus immunity and physician compliance with tetanus prophylaxis practices among emergency department patients presenting with wounds. Ann Emerg Med. 2004. 43:305–314.
3. Alagappan K, Pulido G, Caldwell J, Abrahamian FM. Physician compliance with tetanus guidelines for admitted versus discharged patients. South Med J. 2006. 99:234–238.
4. Abbate R, Di Giuseppe G, Marinelli P, Angelillo IF. Collaborative Working Group. Appropriate tetanus prophylaxis practices in patients attending emergency departments in Italy. Vaccine. 2008. 26:3634–3639.
5. Giangrasso J, Smith RK. Misuse of tetanus immunoprophylaxis in wound care. Ann Emerg Med. 1985. 14:573–579.
6. Lee SY, Kwak GY, Nam CH, Kim JH, Hur JK, Lee KY, Park JS, Kim HM, Kang JH. Immunogenicity and safety of diphtheria-tetanus vaccine in pre-adolescent and adolescent South Koreans. Vaccine. 2009. 27:3209–3212.
7. Dal-Ré R, Gil A, González A, Lasheras L. Does tetanus immune globulin interfere with the immune response to simultaneous administration of tetanus-diphtheria vaccine? J Clin Pharmacol. 1995. 35:420–425.
8. Shin DH, Yu HS, Park JH, Shin JH, Kim SJ. Recently occurring adult tetanus in Korea: emphasis on immunization and awareness of tetanus. J Korean Med Sci. 2003. 18:11–16.
9. Lelie PN, Reesink HW, Grijm R, de Jong-van Manen ST, Reerink-Brongers EE. Simultaneous passive and active immunization against hepatitis B: noninterference of hepatitis B immune globulin with the anti-HBs response to reduced doses of heat-inactivated hepatitis B vaccine. Hepatology. 1986. 6:971–975.
10. Wagner G, Lavanchy D, Darioli R, Pecoud A, Brulein V, Safary A, Frei PC. Simultaneous active and passive immunization against hepatitis A studied in a population of travellers. Vaccine. 1993. 11:1027–1032.
11. National Health and Medical Research Council. Immunoglobulins. 1991. Canberra Australian Government Publishing Service.
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