J Korean Med Sci.
2005 Aug;20(4):687-690. 10.3346/jkms.2005.20.4.687.
Extraskeletal Ewing's Sarcoma of the Hard Palate
- Affiliations
-
- 1Department of Pathology, Pusan Paik Hospital, College of Medicine, Inje University, Busan, Korea. pathkang@inje.ac.kr
- 2Department of Otorhinolaryngology-Head and Neck Surgery, Pusan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
- KMID: 1712757
- DOI: http://doi.org/10.3346/jkms.2005.20.4.687
Abstract
- Extraskeletal Ewing's sarcoma (EES) is a rare soft tissue tumor morphologically indistinguishable from the more common Ewing's sarcoma of bone. We report a case of EES arising in the hard palate of 34-yr-old male patient. Microscopically, the monotonous small round cells without neuronal differentiation showed membranous positive immunoreactivity for MIC2/CD99 and vimentin. Ultrastructurally, the tumor cells showed a few intracytoplasmic organelles without evidence of neurosecretory granules or neurofilaments. The EWS-FLI1 chimeric gene was identified using the nested reverse transcriptase-polymerase chain reaction.
Keyword
MeSH Terms
-
Adult
Antigens, CD/analysis
Cell Adhesion Molecules/analysis
Humans
Immunohistochemistry
Male
Oncogene Proteins, Fusion/genetics
Palatal Neoplasms/genetics/metabolism/*pathology
Palate, Hard/metabolism/*pathology
Proto-Oncogene Protein c-fli-1/genetics
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Ewing's/genetics/metabolism/*pathology
Transcription, Genetic
Vimentin/analysis
