Gut Liver.  2013 Nov;7(6):675-680.

Ischemia-Modified Albumin: Could It Be a New Oxidative Stress Biomarker for Colorectal Carcinoma?

• Ellidag HY
• Bulbuller
• Eren E
• Abusoglu S
• Akgol E
• Cetiner M
• Yilmaz N

Abstract

BACKGROUND/AIMS
An impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified albumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).
METHODS
Forty patients with CRC (19 females and 21 males; mean age, 56.5+/-2.1 years) and 39 age- and sex-matched healthy people (22 females and 17 males; mean age, 56.0+/-1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated.
RESULTS
Serum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32).
CONCLUSIONS
In this study, the oxidative/antioxidant status was impaired in favor of oxidative stress in CRC patients. This observation was not confirmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers.

Keyword

Colorectal neoplasms; Ischemia-modified albumin; Oxidative stress

MeSH Terms

Antioxidants/metabolism
Biological Markers/blood
Case-Control Studies
Colorectal Neoplasms/*blood
Female
Humans
Male
Middle Aged
Oxidants/blood
Oxidative Stress
Prospective Studies
Serum Albumin/metabolism
Tumor Markers, Biological/*blood
Antioxidants
Biological Markers
Oxidants
Serum Albumin
Tumor Markers, Biological