Korean J Med.  2014 Aug;87(2):142-150. 10.3904/kjm.2014.87.2.142.

Recent Guidelines on the Management of Blood Cholesterol: 2013 ACC/AHA Guidelines and 2014 NICE Draft Guidelines

• Hur SH

• KMID: 1710022
• DOI: http://doi.org/10.3904/kjm.2014.87.2.142

Abstract

Low-density lipoprotein (LDL) cholesterol plays a major role in the development and progression of atherosclerosis. Numerous studies have demonstrated that the management of cholesterol, mainly treated with statins, can reduce LDL cholesterol levels and improve clinical outcomes. The American College of Cardiology (ACC) and American Heart Association (AHA) recently released new guidelines that included the new concept of atherosclerotic cardiovascular disease (ASCVD) and pooled cohort equations for estimation of the 10-year ASCVD risk in individuals. Conversely, the draft National Institute for Health and Care Excellence (NICE) guideline is currently being updated following its publication in 2008. This draft guidance introduced the QRISK2 risk assessment tool for the risk of development of cardiovascular disease in the next 10 years and combined with cost effectiveness. Importantly, both guidelines suggested moderate- to high-intensity statin therapy for the primary and secondary prevention of cardiovascular disease. In this article, we focus on the new risk assessments and recommendations for the use of lipid-lowering therapy in each guideline.

Keyword

Guideline; Cholesterol; Statins; HMG-CoA; Cardiovascular diseases

MeSH Terms

American Heart Association
Atherosclerosis
Cardiology
Cardiovascular Diseases
Cholesterol*
Cholesterol, LDL
Cohort Studies
Cost-Benefit Analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins
Publications
Risk Assessment
Secondary Prevention
Cholesterol
Cholesterol, LDL
Lipoproteins