Lab Anim Res.
2014 Jun;30(2):90-93. 10.5625/lar.2014.30.2.90.
No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
- Affiliations
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- 1National Institute of Animal Science, Suwon, Korea. imseoki@rda.go.kr
- 2Pusan National University, Busan, Korea.
- 3Orient Genia Inc., Seongnam, Korea.
- 4Konkuk University School of Medicine, Seoul, Korea.
- 5Seoul National University College of Medicine, Seoul, Korea.
- KMID: 1707449
- DOI: http://doi.org/10.5625/lar.2014.30.2.90
Abstract
- This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from alpha-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
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