Korean J Pediatr Infect Dis.  2014 Apr;21(1):53-58.

A Case of Esophageal Obstruction Complicated in a Patient with Chronic Granulomatous Disease: Esophageal obstruction in Chronic Granulomatous Disease

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. jgkim@snu.ac.kr
  • 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Chronic granulomatous disease (CGD) is an inherited immunodeficient disease characterized by recurrent infections and granuloma formation. Granulomatous obstruction of esophagus is one of the rare complications of CGD. The use of steroids and antimicrobials for esophageal obstruction by granuloma in CGD patients has been controversial due to the possibility of concomitant inapparent infection. We report a case of esophageal obstruction in an 8-year-old CGD patient showing the poor response to antibiotics therapy. However, dramatic improvement of symptoms and radiologic findings of esophageal obstruction were achieved after steroid therapy. One month after discontinuation of steroid, esophageal obstruction recurred and the patient was re-treated with steroid. After that time, he experienced one more recurrence of esophageal obstruction. This symptom subsided after antibiotics therapy without steroid and he has been followed up to the present without further relapse.

Keyword

Chronic granulomatous disease; Esophageal stenosis; Steroid

MeSH Terms

Anti-Bacterial Agents
Child
Esophageal Stenosis
Esophagus
Granuloma
Granulomatous Disease, Chronic*
Humans
Recurrence
Steroids
Anti-Bacterial Agents
Steroids
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