J Korean Soc Magn Reson Med.  2014 Mar;18(1):34-42. 10.13104/jksmrm.2014.18.1.34.

Investigation of Correlations of Double Inversion Recovery and MR Spectroscopy on Breast MR Imaging

• Ryu JK
• Rhee SJ
• Jahng GH

• KMID: 1683778
• DOI: http://doi.org/10.13104/jksmrm.2014.18.1.34

Abstract

PURPOSE
To evaluate the correlation of lesion-to-normal ratio (LNR) of signal intensity from double inversion recovery MR imaging and total choline-containing compound (tCho) resonance from single voxel MR spectroscopy in breast cancers.
MATERIALS AND METHODS
Between August 2008 and December 2009, 28 patients who were diagnosed as breast cancer and had undergone both double inversion recovery (DIR) MR imaging and MR spectroscopy (MRS) were included in this study. The signal intensities of the lesion (L) and ipsilateral normal breast tissue (N) were measured in region of interest of each breast cancer in DIR and contrast enhance MR image (CE-T1WI) to calculate the LNR value for each technique. MRS was performed using single-voxel MR spectroscopy. The height, width and area of tCho resonance were compared with each LNR of DIR and CE-T1WI. We used Pearson's correlation coefficient (r) for correlation analysis and the significance level was p=0.05.
RESULTS
There was no statistically significant correlation between LNR of CE-T1WI and height (r=-0.322, p=0.094), width (r=-0.233, p=0.232) and area (r=-0.309, p=0.109) of MRS tCho. There was no statistically significant correlation between LNR of DIR and height (r=0.067, p=0.735), width (r=-0.287, p=0.139) and area (r=0.012, p=0.953) of MRS tCho, either. The Pearson's correlation coefficient was 0.186 between LNRs of CE-T1WI and DIR (p=0.344).
CONCLUSION
There was no statistically significant correlation between LNR of DIR and relative amount of tCho resonance of MRS.

Keyword

Breast MRI; Double inversion recovery; MR spectroscopy; Breast cancer; Correlation

MeSH Terms

Breast Neoplasms
Breast*
Humans
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*

Figure

• 

  Fig. 1 Representative double inversion recovery (DIR) image and MRS spectrum on a patient with invasive ductal carcinoma in 47-year-old woman. a. About 3.0 cm sized rim enhancing oval mass was noted at upper central portion of the right breast in sagittal scan of contrast-enhanced T1-weighted imaging (CE-T1WI). b. In sagittal DIR image, the mass shows the bright high signal intensity compared with that of normal parenchyma which results the lesion more conspicuous. c. Single-voxel MR spectroscopy reveals prominent tCho resonance peak at 3.2ppm. The height, width and area of the tCho were 1.068, 0.1 and 0.120, respectively.

• 

  Fig. 2 Representative double inversion recovery (DIR) image and MRS spectrum on a patient with mucinous carcinoma in 66-year-old woman. a. About 2.5 cm sized heterogenous enhancing mass was shown at the left central breast in sagittal contrast-enhanced T1-weighted imaging (CE-T1WI). b. Axial scan of DIR image represents rather iso- to low signal intensity mass at the left central breast. c. At 3.2ppm resonance, a striking tCho peak was visualized with the height, width and area as 0.526, 0.11 and c 0.065, respectively.

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