Korean J Dermatol.  1982 Dec;20(6):971-975.

A Giant Squamous Cell Carcinoma Arising in the Lesion of Discoid Lupus Erythematosus

• Son YH
• Kim HB
• Cha JS
• Kim MY

Abstract

In the past, irritant or radiation therapy have been used to treat discoid lupus erythematosus, therefore malignant and proriferative change in the lesion of discoid lupus erythematosus were not uncommon. In recent year, however, because the preferred treatment of discoid lups erythematosus consisted of steroids and antimalarials, the association with squamous cell carcinoma has been extremely rare. We present a case of giant squamous cell carcinoma arising in the discoid lupus erythematosus in 39 year-old women. She had had a 20 year history of facial discoid lupus erythematoseus. In September of 1976, a thumb tip-sized tumor mass found on the right cheek and the maas grew into the adult palm size rapidly. The tumor show ulceration, serosanguinous discharge, easy bleeding, and foul oder. Histopathologically, the specimen obtained from plaques of the left cheek showed hyperkeratosis with plugging, atrophy of the stratum malpighii, a patchy, chiefly lymphoid cell infiltrate with a tendency to arrangement about the cutaneous appendages, hydropic degeneration of the basal cells, edema and vasodilatation in the dermis. The specimen obtained from tumor mass of the right cheek showed many nests consisted of well differentiated squamous cells, keratin pearls.

MeSH Terms

Adult
Antimalarials
Atrophy
Carcinoma, Squamous Cell*
Cheek
Dermis
Edema
Female
Hemorrhage
Humans
Lupus Erythematosus, Discoid*
Lymphocytes
Steroids
Thumb
Ulcer
Vasodilation
Antimalarials
Steroids