J Korean Neurol Assoc.  2005 Jun;23(3):313-317.

Incidence of Patent Foramen Ovale in Ischemic Stroke Patients: A Transcranial Doppler Study

Affiliations
  • 1Department of Neurology, Kyunghee University College of Medicine, Seoul, Korea. dichang@khmc.or.kr

Abstract

BACKGROUND
Patent foramen ovale (PFO) is increasingly being recognized in stroke patients. The capability of transcranial Doppler (TCD) to detect a PFO has been established. We studied the frequency of PFO in patients with ischemic stroke. METHODS: Eighty-nine patients with ischemic stroke (62 men, mean age: 56.5) consecutively underwent a contrast-enhanced TCD with monitoring of the bilateral middle cerebral arteries (MCA). The contrast solution, which consisted of 8 ml of normal saline, 1 ml of air, and 0.2 ml of patient's blood, was injected twice during normal breathing and the Valsalva maneuver. High intensity transient signals (HITS) were counted for 30 seconds after the injection. RESULTS: Patent foramen ovale was detected in 19 patients (21%). The mean age was similar in those with (55 years) and those without (57 years) PFO. Patent foramen ovale was more frequent among men (26%) than women (11%). There were no differences in the frequency of PFO among stroke subtypes (large artery atherosclerosis, 18%; small artery occlusion, 27%; cardioembolic, 27%; undetermined cause, 11%). CONCLUSIONS: Patent foramen ovale is common in patients with ischemic stroke of all subtypes.

Keyword

Patent foramen ovale; Ischemic stroke

MeSH Terms

Arteries
Atherosclerosis
Female
Foramen Ovale, Patent*
Humans
Incidence*
Male
Middle Cerebral Artery
Respiration
Stroke*
Valsalva Maneuver
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