Korean Circ J.  2003 Mar;33(3):233-241. 10.4070/kcj.2003.33.3.233.

Clinical Usefulness of the Second Derivative of a Photoplethysmogram Waveform(SDPTG)

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES
The second derivative of a photoplethysmogram (SDPTG) is a simple, convenient and non-invasive technique for pulse wave analysis. The SDPTG index correlates with age and other risk factors of atherosclerosis in the Japanese population, but has not yet been described in the Korean population. The purposes of this study were to analyze the age-related changes in the SDPTG of healthy subjects (study 1), and investigate the differences in the SDPTG of patients with hypertension, compared with those of normotensive subjects (study 2). We also compared the differences in the SDPTG between coronary artery disease (CAD) patients and normal subjects (study 3), to test the clinical usefulness of SDPTG in the evaluation of atherosclerosis.
SUBJECTS AND METHODS
We consecutively studied 235 healthy adults, 40 with essential hypertension and 42 with CAD. Their SDPTG were recorded in the sitting position using a Fukuda FCP-3166.
RESULTS
In study 1, the b/a ratio increased with age, whereas the c/a, d/a and e/a ratios decreased. The SDPTG aging index (AGI)(y) increased with age (x)(r=0.71, p=0.000;y=22.731x+54.571). In study 2, the patients with hypertension showed a lower average d/a ratio (-0.47+/-0.15 vs. -0.38+/-0.15, p=0.02) and higher average SDPTG AGI (-0.09+/-0.34 vs. -0.26+/-0.37, p=0.011) than the normotensive subjects. In study 3, the patients with CAD had higher average b/a ratio (-0.47+/-0.19 vs. -0.59+/-0.17, p=0.001) and SDPTG AGI (-0.01+/-0.41 vs. -0.23+/-0.40, p=0.004) than the normal subjects. In a logistic regression analysis, the SDPTG AGI was a significant determinant of CAD (p=0.046).
CONCLUSION
The SDPTG aging index may be useful in the evaluation of vascular aging and damage due to hypertension and atherosclerosis.

Keyword

Photoplethysmography; Hypertension; Coronary arteriosclerosis

MeSH Terms

Adult
Aging
Asian Continental Ancestry Group
Atherosclerosis
Coronary Artery Disease
Humans
Hypertension
Logistic Models
Photoplethysmography
Pulse Wave Analysis
Risk Factors
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