Chonnam Med J.  2003 Sep;39(3):202-206.

A Case of Multiple Symmetric Lipomatosis Associated with Hepatocellular Carcinoma, Alcoholic Liver Cirrhosis and Cardiomyopathy

• Namgung KY
• Kang MJ
• Im HM
• Oh SJ
• Ahn HT

Abstract

Multiple symmetric lipomatosis, also called Madelung's disease is characterized by progressive enlargement of subcutaneous symmetric fat deposits on the neck, shoulder girdle and arms, giving the patient a pseudoathletic appearance. The development of multiple symmetric lipomatosis is highly related with alcoholism. Many of these patients have other metabolic disorders including hyperlipidemia, hyperuricemia, reduced glucose tolerance and renal tubular acidosis. Also, Excessive alcohol intake is associated with liver disease, central nervous system disorder, alcoholic myopathy and cardiomyopathy. The liver is the organ most severely affected in patients with alcoholism, reulting in liver cirrhosis and hepatocellular carcinoma. Also, alcohol drinking has been implicated as a risk factor for dilated cardiomyopathy. We report a case of multiple symmetric lipomatosis diagnosed during follow-up of a patient suffering from hepatocellular carcinoma, liver cirrhosis and alcoholic cardiomyopathy.

Keyword

Multiple symmetrical lipomatosis; Alcoholism; Hepatocelluar carcinoma; Alcoholic cardiomyopathy

MeSH Terms

Acidosis, Renal Tubular
Alcohol Drinking
Alcoholics*
Alcoholism
Arm
Carcinoma, Hepatocellular*
Cardiomyopathies*
Cardiomyopathy, Alcoholic
Cardiomyopathy, Dilated
Central Nervous System
Follow-Up Studies
Glucose
Humans
Hyperlipidemias
Hyperuricemia
Lipomatosis, Multiple Symmetrical*
Liver
Liver Cirrhosis
Liver Cirrhosis, Alcoholic*
Liver Diseases
Muscular Diseases
Neck
Risk Factors
Shoulder
Glucose