Korean J Physiol Pharmacol.
2003 Feb;7(1):29-31.
Apo-1/Fas (CD95) Gene Polymorphism in Korean Hepatocellular Carcinoma Patients
- Affiliations
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- 1Department of Pharmacology, College of Medicine, Kangwon National University, Kangwon-do 200-701, Korea. ysvin@kangwon.ac.kr
- 2Division of Rheumatology, Department of Internal Medicine, College of Medicine, KyungHee University, Seoul, Korea.
- 3Division of Hemato- oncology, Department of Internal Medicine, Seoul Veterans Hospital, Korea.
- 4Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- 5Department of Orthopaedic Surgery, College of Medicine, Kangwon National University, Chuncheon, Korea.
- 6Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul 130-701, Korea.
- 7Department of Anatomy, College of Medicine, Seoul National University, Korea.
- 8Division of Medical Oncology, Korea Cancer Center Hospital, Seoul 130-706, Korea.
Abstract
- It is well known that different expression of Apo-1/Fas (CD95) plays important roles in various tumors and hepatocellular carcinoma (HCC) pathogenesis. Apo-1/Fas mediated apoptosis is one of the important pathways of apoptosis and is known to mediate apoptotic cell death by fas ligand (FasL). To examine the possible relationship between Apo-1/Fas gene polymorphism and HCC susceptibility, MvaI restriction fragment length polymorphism (RFLP) of Apo-1/Fas gene was examined in 94 Korean HCC patients and 240 control subjects. No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the HCC. It is, therefore, concluded that Apo-1/Fas gene polymorphism is not associated with HCC susceptibility. Further studies are needed in order to clarify the relationships between genotypes of Apo-1/Fas gene and HCC pathogenesis.
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