Korean J Otolaryngol-Head Neck Surg.  2006 Dec;49(12):1172-1175.

The Effects of Eosinophils Activated with Airborne Fungi on Nasal Epithelial Cells

Affiliations
  • 1Department of Otolaryngology, School of Medicine, Catholic University of Daegu, Daegu, Korea. hsseung@cu.ac.kr

Abstract

BACKGROUND AND OBJECTIVES
The eosinophils are involved in physiologic and pathologic process, such as asthma, parasitic disease, and nasal diseases. In chronic rhinosinusitis (CRS), most of the eosinophils in nasal cavity were activated with extracellular deposition of granule proteins. The nasal epithelial cells are an active participant in airway inflammation. The aim of this study is to know the influence of activated eosinophils on nasal epithelial cells. SUBJECTS AND METHOD: Eosinophils were isolated from healthy volunteers and stimulated with three common fungi (Alternaria, Aspergillus, and Bipolaris) to obtain conditioned media (EoCM). Nasal epithelial cells were obtained from CRS patients with polyps and cultured with EoCM for 48 hours. Interleukin-6 (IL-6), IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) were measured to determine the activation of epithelial cells.
RESULTS
Nasal epithelial cells stimulated with EoCM produced larger amount of IL-6, IL-8 and GM-CSF than negative controls (p<0.05).
CONCLUSION
Fungi induced the production of chemical mediators from eosinophils and EoCM enhanced the production of inflammatory cytokines which may influence the pathogenesis of CRS.

Keyword

Eosinophil; Fungus; Activation; Epithelial cell
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