Cancer Res Treat.  2002 Dec;34(6):439-443.

High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Persistent/Relapsed Ovarian Cancer

Affiliations
  • 1Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Seoul, Korea. jhwon@hosp.sch.ac.kr
  • 2Department of Internal Medicine, Ajou University College of Medicine, Suwon, Korea.

Abstract

PURPOSE: High dose chemotherapy (HDC) is increasingly being used for ovarian cancer. Although early studies of autotransplantation for advanced ovarian cancer have been encouraging, most reported series were small, and no randomized trials have been reported. HDC and autologous hematopoietic stem cell transplantation were rarely performed in patients with ovarian cancer in Korea, and no results have been reported with the exception of one case report.
MATERIALS AND METHODS
We retrospectively analyzed 10 patients with refractory or relapsed ovarian cancer having received HDC and autologous peripheral blood stem cell transplantation (APBSCT), between January 1996 and September 1998, at the Soon Chun Hyang and Ajou University Hospitals.
RESULTS
Ten patients were treated with HDC and APBSCT. Six patients achieved complete response (CR) and 1 a partial response (PR), with a response rate of 70%. Three patients did not respond following mobilization chemotherapy, and failed to respond after HDC. The median duration of progression free survival (PFS) and overall survival (OS) were 6 (4~46) and 13 (3~50+) months, respectively. The median duration of OS of the responders following mobilization chemotherapy was 23 (8~50+) compared with 12 (3~18) months of the non- responders. With regard to the treatment related toxicity, 8 patients had neutropenic fevers, and bacteremia was documented in 4. The non-hematological toxicities were never life threatening, and there were no treatment related deaths.
CONCLUSION
HDC, followed by APBSCT, is well-tolerated patients with refractory or relapsed ovarian cancer, and following mobilization chemotherapy the responders survived longer than the non-responders.

Keyword

Ovarian neoplasm; High dose chemotherapy; Stem cell transplantation

MeSH Terms

Autografts
Bacteremia
Disease-Free Survival
Drug Therapy*
Fever
Hematopoietic Stem Cell Transplantation
Hospitals, University
Humans
Korea
Ovarian Neoplasms*
Peripheral Blood Stem Cell Transplantation*
Retrospective Studies
Stem Cell Transplantation
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