J Korean Gastric Cancer Assoc.  2006 Dec;6(4):237-243.

Prognosis and Treatment Outcomes of Gastric Cancer Patients with Hepatic Metastasis

Affiliations
  • 1Department of Surgery, Yeungnam Medical Center, Yeungnam University, Daegu, Korea. sksong@med.yu.ac.kr
  • 2Department of Hemato-oncology, Yeungnam Medical Center, Yeungnam University, Daegu, Korea.
  • 3Department of Diagnostic Radiology, Yeungnam Medical Center, Yeungnam University, Daegu, Korea.

Abstract

PURPOSE: This study was conducted to evaluate the treatment outcomes and the prognosis for gastric cancer patients with hepatic metastasis.
MATERIALS AND METHODS
This retrospective study was based on the medical records of 85 gastric cancer patients with hepatic metastasis (62 synchronous and, 23 metachronous) who received chemotherapy with or without resectional therapy from March 1990 to March 2006. The survival rate was analyzed according to clinicopathologic factors and therapeutic factors, such as whether or not a gastrectomy, a hepatic resection, and/or chemotherapy had been performed.
RESULTS
The median survival of gastric cancer patients with hepatic metastasis was 11 months (synchronous: 11 months and metachronous: 17 months). The rates of gastrectomies and hepatic resections in the synchronous group were 24.1% and 16.1%, respectively. A 23.5% prevalence of extra-hepatic metastasis was observed. The median survivals of patients who underwent a gastrectomy with a hepatic resection, a gastrectomy alone, and non-surgical treatment were 60, 18, and 9 months, respectively (P<0.05). The disease-free median survival of the metachronous group was 8 (3~39) months. There was no difference in initial pathologic stage and frequency of hepatic metastasis after the gastrectomy in the metachronous group. In the synchronous group, extra-hepatic metastasis, a gastrectomy as the operative procedure, a hepatic resection as the operative procedure and the response to chemotherapy were statistically significant in the univariate analysis, and a hepatic resection as the operative procedure, the response to chemotherapy, and extra-hepatic metastasis were independant prognostic factors identified by the multivariate analysis. In the metachronous group, extra-hepatic metastasis, the response to chemotherapy and differentiation were statistically significant in the univariate analysis, and extra-hepatic metastasis was an independent prognostic factor identified by the multivariate analysis.
CONCLUSION
An aggressive surgical therapy and effective chemotherapy are necessary in the treatment of gastric cancer patients with hepatic metastasis.

Keyword

Prognosis; Synchronous; Metachronous; Hepatic metastasis; Gastric cancer

MeSH Terms

Drug Therapy
Gastrectomy
Humans
Medical Records
Multivariate Analysis
Neoplasm Metastasis*
Prevalence
Prognosis*
Retrospective Studies
Stomach Neoplasms*
Surgical Procedures, Operative
Survival Rate
Full Text Links
  • JKGCA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr