Hanyang Med Rev.  2007 Aug;27(3):76-91.

Antibiotic Resistance in Helicobacter pylori

Affiliations
  • 1Department of Microbiology, Hanyang University College of Medicine, Korea. jungmogg@hanyang.ac.kr

Abstract

Although Helicobacter pylori is susceptible to many antibiotics in vitro, only a few antibiotics, including amoxicillin, clarithromycin, metronidazole, tetracycline, and fluoroquinolones, have been frequently used in vivo to cure the infection in Korea. However, the frequent use for treatment regimens incorporating a proton pump inhibitor (PPI) and a combination of two or more antibiotics has resulted in the development of antibiotic resistance against H. pylori, which is a growing problem. The frequencies of resistance to antibiotics have varied widely according to geographical regions and subgroups within study populations. In this review article the prevalence of antibiotic resistance in H. pylori isolated from Korean patients, molecular mechanisms of the resistance and methods to detect the resistance have been discussed.

Keyword

Antibiotics; Helicobacter pylori; MIC; Resistance

MeSH Terms

Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Drug Resistance, Microbial*
Fluoroquinolones
Helicobacter pylori*
Helicobacter*
Humans
Korea
Metronidazole
Prevalence
Proton Pumps
Tetracycline
Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Fluoroquinolones
Metronidazole
Proton Pumps
Tetracycline
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