Korean J Gastrointest Endosc.  2007 Sep;35(3):205-209.

A Case of Autoimmune Pancreatitis Diagnosed by Immunohistochemical Staining of IgG4

Affiliations
  • 1Department of Internal Medicine, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea. ktcool.lee@samsung.com
  • 2Department of Pathology, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.

Abstract

Autoimmune pancreatitis is a distinct entity with characteristic morphological, histological and clinical features. Since the first report in 1961, there have been many reports on autoantibodies associated with autoimmune pancreatitis. Lymphoplasmacytic infiltration with fibrosis is the characteristic histological feature of autoimmune pancreatitis. Elevation of immunoglobulin G4 (IgG4), a subtype of IgG, can be seen in autoimmune pancreatitis. A few reports of autoimmune pancreatitis based on immunostaining of IgG4 have been published, but no reports have been published in Korea. We present here the first report of autoimmune pancreatitis, based on an increased serum IgG4 level and plasma cell infiltration that showed IgG4 positivity by immunohistochemical staining of the major papilla.

Keyword

Autoimmune pancreatitis; Immunoglobulin G4
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