J Korean Soc Endocrinol.  2004 Oct;19(5):492-500.

Relationship between Serum Adiponectin and Development of the Metabolic Syndrome

• Park SS
• Choi KM
• Kwon SB
• Ryu OH
• Ryu HJ
• Park SY
• Kim HY
• Seo JA
• Lee KW
• Kim SG
• Kim NH
• Choi DS
• Baik SH

Abstract

BACKGROUND: We investigated whether low serum adiponectin concentrations are able to predict the future development of type 2 diabetes and metabolic syndrome.
METHODS
This was a prospective cohort study, which included 372 elderly Koreans that participated in the South-West Seoul (SWS) study, conducted in 1999 and 2002 in Seoul, Korea. Fasting and post-challenge 2-hour plasma glucose, body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, lipid profiles, and serum adiponectin data were examined.
RESULTS
Adiponectin concentrations obtained in 1999 and 2002 were highly correlated (r = 0.63, P < 0.0001), and the three-year within-person variation of the adiponectin concentrations was not significant (P=0.61). The serum adiponectin level was closely correlated with metabolic syndrome; negatively with BMI, WHR, blood pressure, triglyceride and blood glucose, and positively with HDL cholesterol. Subjects with metabolic syndrome showed lower serum adiponectin concentrations than those without (P < 0.0001). The baseline adiponectin levels were found to be correlated with subsequent changes in the WHR, LDL cholesterol, and fasting and post-load 2h glucose over the 3-year period, after adjusting the baseline values. A multiple logistic regression analysis showed that lower baseline serum adiponectin concentrations were significantly associated with the developments of type 2 diabetes and the metabolic syndrome after adjusting for age, gender, obesity, history of impaired fasting glucose or impaired glucose tolerance, hypertension and dyslipidemia.
CONCLUSION
Reduced concentrations of adiponectin were found to be independently associated with increase risks of both type 2 diabetes and metabolic syndrome in elderly Koreans

MeSH Terms

Adiponectin*
Aged
Blood Glucose
Blood Pressure
Body Mass Index
Cholesterol, HDL
Cholesterol, LDL
Cohort Studies
Dyslipidemias
Fasting
Glucose
Humans
Hypertension
Insulin Resistance
Korea
Logistic Models
Obesity
Prospective Studies
Seoul
Triglycerides
Waist-Hip Ratio
Adiponectin
Blood Glucose
Cholesterol, HDL
Cholesterol, LDL
Glucose