Korean J Obes.
2007 Mar;16(1):1-5.
The Change of Plasma Ghrelin and Peptide YY3-36 Levels after Meal
- Affiliations
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- 1Center for Obesity, Nutrition and Metabolism, Pusan National University Hospital, Korea.
- 2Department of Laboratory Medicine, Pusan National University Hospital, Korea.
- 3Department of Surgery, Pusan National University Hospital, Korea. saylee@pnu.edu
- 4Department of Physical Education, Pusan National University College of Education, Korea.
Abstract
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BACKGROUND: Ghrelin and Peptide YY3-36 are gastrointestinal hormones related energy homeostasis. We investigated the changes in post-meal plasma ghrelin and PYY3-36 levels in people after meal, simultaneously.
METHODS
Nine healthy volunteers adhered to strict meal times starting two weeks before the study. Blood was drawn hourly for 4 hours. Plasma ghrelin, PYY3-36, leptin, and insulin levels were measured by radioimmunoassay (RIA).
RESULTS
The mean plasma ghrelin level in subjects consuming the meal was 588.0 +/- 204.4 pg/mL just before breakfast and 394.22 +/- 145.25 pg/mL 1 h after meal, with the mean plasma PYY3-36 levels of 29.9 +/- 13.7 pmol/L and 44.2 +/- 12.1 pmol/L, respectively. The mean plasma leptin level in subjects consuming the meal was 7.4 +/- 2.7 ng/mL before the meal and 7.1 +/- 2.9 ng/mL 1 h after meal, with insulin levels of 129.8 +/- 50.0 pmol/L and 658.8 +/- 332.3 pmol/L, respectively. Plasma ghrelin levels were lowest 1 h after the meal, although PYY3-36 levels were highest 1 h after the meal.
CONCLUSION
While plasma ghrelin levels were lowest 1 h, PYY3-36 levels were highest 1 h after the meal. These findings suggest that Plasma ghrelin and peptide YY3-36 levels change in opposite ways at the same speed.
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