Korean J Fertil Steril.  2006 Mar;33(1):45-52.

A Study of Altered IL-6 and TNF-alpha Expression in Peritoneal Fluid of Patients with Endometriosis

Affiliations
  • 1Department of Obstetrics and Gynecology, Hallym University, College of Medicine, Anyang, Korea. kjb0001@hallym.or.kr
  • 2Department of Laboratory Medicine, Hallym University, College of Medicine, Anyang, Korea.

Abstract


OBJECTIVE
Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-alpha in the peritoneal fluid of women with and without endometriosis and infertile women.
METHODS
This study is prospective and case-control study in University hospital, enrolled thirty-four women with laparoscopic findings of minimal to severe endometriosis, and thirty-seven women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. IL-6 and tumor necrosis factor-alpha levels in peritoneal fluid were determined using commercial ELISA. IL-6 and tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification.
RESULTS
IL-6 and tumor necrosis factor-alpha concentrations were higher than in the peritoneal fluid of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in peritoneal fluid from patients with endometriosis: the concentrations in the secretory phase were significantly higher than those in the proliferative phase. The concentrations were higher than among of infertile women than in fertile women. A significant correlation between IL-6 and tumor necrosis factor-alpha concentrations and endometriosis stage III and IV was noted.
CONCLUSION
Increased levels of IL-6 and tumor necrosis factor-alpha in patients with endometriosis in the peritoneal fluid may be relate to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.

Keyword

Endometriosis; Interleukin-6; Tumor necrosis factor-alpha

MeSH Terms

Ascitic Fluid*
Case-Control Studies
Classification
Endometriosis*
Enzyme-Linked Immunosorbent Assay
Female
Fertility
Genital Diseases, Female
Humans
Interleukin-6*
Prospective Studies
Tumor Necrosis Factor-alpha*
Interleukin-6
Tumor Necrosis Factor-alpha
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