Immune Netw.  2014 Feb;14(1):14-20. 10.4110/in.2014.14.1.14.

NF-kappaB Activation in T Helper 17 Cell Differentiation

• Park SH
• Cho G
• Park SG

• KMID: 1508824
• DOI: http://doi.org/10.4110/in.2014.14.1.14

Abstract

CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-kappaB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-kappaB activation pathway and its effect on Th17 cell differentiation.

Keyword

NF-kappaB; Th17; T cell receptor; Autoimmune

MeSH Terms

Cell Differentiation*
Cell Survival
Gene Expression
Ligation
NF-kappa B*
Receptors, Antigen, T-Cell
Th17 Cells
NF-kappa B
Receptors, Antigen, T-Cell

Figure

• 

  Figure 1 NF-κB family. The mammalian NF-κB protein family consists of five members: p65 (RelA), RelB, c-Rel, NF-κB2 (precursor, p100; mature form, p52), and NF-κB1 (precursor, p105; mature form, p50).

• 

  Figure 2 T cell receptor-mediated NF-κB activation. T cell receptor complex and CD28-mediated PDK1 activation are important for signaling complex formation composed of PKCθ, Carma1, Bcl10, and Malt1. This signaling complex leads to IKK complex activation and subsequently activates NF-κB during T cell activation by antigen.

• 

  Figure 3 Effect of NF-κB activation on Th17 cell differentiation. NF-κB activation in antigen presenting cells is important for production of Th17 cell differentiation cytokines. Some research groups report that NF-κB activation in CD4 T cells positively regulates Th17 cell differentiation while others showed that NF-κB activation does not affect or negatively regulates Th17 cell differentiation.

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