Immune Netw.  2014 Feb;14(1):14-20. 10.4110/in.2014.14.1.14.

NF-kappaB Activation in T Helper 17 Cell Differentiation

Affiliations
  • 1School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea. sgpark@gist.ac.kr

Abstract

CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-kappaB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-kappaB activation pathway and its effect on Th17 cell differentiation.

Keyword

NF-kappaB; Th17; T cell receptor; Autoimmune
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