Korean J Ophthalmol.  2012 Dec;26(6):478-480. 10.3341/kjo.2012.26.6.478.

Photodynamic Therapy Combined with Intravitreal Bevacizumab in a Patient with Choroidal Neovascularization Secondary to Choroidal Osteoma

• Jang JH
• Kim KH
• Lee SJ
• Park JM

• KMID: 1499690
• DOI: http://doi.org/10.3341/kjo.2012.26.6.478

Abstract

Choroidal osteoma is a benign ossified tumor that is found predominantly in healthy young women during their second and third decades of life. The lesions are white-to-cream or orange in color, are located in the peripapillary and macular areas, and are unilateral in most patients. The symptoms of choroidal osteoma include decreased visual acuity and metamorphopsia or scotoma corresponding to the location of the osteoma, but some patients have no symptoms. Prognosis of vision varies according to tumor location, retinal pigment epithelial and sensory retinal degeneration, subretinal fluid and hemorrhage, and development of a subretinal neovascular membrane.

Keyword

Bevacizumab; Choroidal osteoma; Photochemotherapy

MeSH Terms

Angiogenesis Inhibitors/administration & dosage
Antibodies, Monoclonal, Humanized/*administration & dosage
Choroid Neoplasms/*complications/diagnosis
Choroidal Neovascularization/diagnosis/*drug therapy/etiology
Female
Fluorescein Angiography
Humans
Intravitreal Injections
Middle Aged
Osteoma/*complications/diagnosis
Photochemotherapy/*methods
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A/antagonists & inhibitors
Visual Acuity
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Vascular Endothelial Growth Factor A

Figure

• 

  Fig. 1 (A) Fundus photography showed a choroidal osteoma with subretinal hemorrhage, suggestive of choroidal neovascularization (CNV). (B) Fundus photography (2 weeks after treatment) showed decreased subretinal hemorrhage and decalcification of the tumor. (C) Optical coherence tomography showed the presence of CNV. (D) Optical coherence tomography (12 weeks after treatment) showed CNV. (E) Fluorecein angiography showed irregular hyperfluorecence, leakage confirmed intense CNV staining in the late stages. (F) Fluorecein angiography showed (12 weeks after treatment) that dye leakage had decreased during the late stages.

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