Korean J Pediatr.  2008 Dec;51(12):1359-1362. 10.3345/kjp.2008.51.12.1359.

Availability of peripheral inserted central catheters in severe hemophilia patients with inhibitors

Affiliations
  • 1Department of Pediatrics, East-West Neo Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea. pysmd@khnmc.or.kr

Abstract

The most effective treatment strategy for patients with hemophilia is replacement therapy with FVIII or FIXconcentrates, which usually requires long-term, uncomplicated venous access. However, central venous access device (CVADs, ports) insertion requires inpatient admission and general anesthesia, and presents some problems regarding health insurance coverage. Peripherally inserted central catheters (PICCs) were inserted in two severe hemophilia patients aged 7 and 11 years with high titers of inhibitors. They experienced frequent bleeding episodes and required replacement therapy, which eventually resulted in difficulty in acquiring venous line access. Factor VIII activity was below 1%, and inhibitor titers were 160 and 26.3 BU/ml. In an outpatient setting, PICC lines are easily placed by radiological guidance and require local anesthesia alone. PICC has been feasible, in particular, for hemophilia patients with frequent bleeding episodes.

Keyword

Hemophilia; Peripherally inserted central catheter

MeSH Terms

Aged
Anesthesia, General
Anesthesia, Local
Catheters
Factor VIII
Hemophilia A
Hemorrhage
Humans
Inpatients
Insurance, Health
Outpatients
Factor VIII
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