Clin Mol Hepatol.  2013 Mar;19(1):1-16. 10.3350/cmh.2013.19.1.1.

Current consensus and guidelines of contrast enhanced ultrasound for the characterization of focal liver lesions

Affiliations
  • 1Institute for Digestive Research, Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 3Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
  • 4Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
  • 6Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
  • 7Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. wytak@knu.ac.kr
  • 8Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
  • 9Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
  • 10KASCU (Korean Association for the Study of Contrast Enhanced Ultrasonography), Korea.

Abstract

The application of ultrasound contrast agents (UCAs) is considered essential when evaluating focal liver lesions (FLLs) using ultrasonography (US). Microbubble UCAs are easy to use and robust; their use poses no risk of nephrotoxicity and requires no ionizing radiation. The unique features of contrast enhanced US (CEUS) are not only noninvasiveness but also real-time assessing of liver perfusion throughout the vascular phases. The later feature has led to dramatic improvement in the diagnostic accuracy of US for detection and characterization of FLLs as well as the guidance to therapeutic procedures and evaluation of response to treatment. This article describes the current consensus and guidelines for the use of UCAs for the FLLs that are commonly encountered in US. After a brief description of the bases of different CEUS techniques, contrast-enhancement patterns of different types of benign and malignant FLLs and other clinical applications are described and discussed on the basis of our experience and the literature data.

Keyword

Guidelines; Contrast enhanced Ultrasonography (CEUS); Focal liver lesions (FLLs)

MeSH Terms

Contrast Media/chemistry/*diagnostic use
Humans
Liver Diseases/radiography/*ultrasonography
Liver Neoplasms/radiography/*ultrasonography
Phospholipids/chemistry/diagnostic use
Practice Guidelines as Topic
Sulfur Hexafluoride/chemistry/diagnostic use
Tomography, X-Ray Computed
Contrast Media
Phospholipids
Sulfur Hexafluoride
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