Infect Chemother.  2008 Feb;40(1):49-51. 10.3947/ic.2008.40.1.49.

In Vitro Susceptibility of piperacillin/tazobactam Against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae

• Kim EC

• KMID: 1483477
• DOI: http://doi.org/10.3947/ic.2008.40.1.49

Abstract

Minimal inhibitory concentrations (MIC) of piperacillin/tazobactam were determined on 20 clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing E. coli and 30 isolates of ESBL- producing Klebsiella pneumoniae. MIC50 and MIC90 for ESBL-producing E. coli were 8/4 microg/ml and 256/4 microg/mL, respectively. MIC50 and MIC90 for ESBL-producing K. pneumoniae were 8/4 microg/mL and > 512/4 microg/mL, respectively. The susceptibilities of ESBL-producing E. coli and K. pneumoniae to piperacillin/tazobactam were 80% and 60%, respectively. Of 20 ESBL-producing E. coli strains, 11 (55%) were TEM-and CTX-M-positive, and SHV-negative. Of 30 ESBL-producing K. pneumoniae strains, ten (33%) were PCR positive for SHV and negative for TEM and CTX-M.

Keyword

Piperacillin/tazobactam; ESBL-producing E. coli; ESBL-producing K. pneumoniae

MeSH Terms

beta-Lactamases
Escherichia
Escherichia coli
Klebsiella
Klebsiella pneumoniae
Pneumonia
Polymerase Chain Reaction
beta-Lactamases