Korean J Nephrol.  2008 Sep;27(5):606-610.

An Adult Case of Tubulointerstitial Nephritis and Uveitis Syndrome in Korea

Affiliations
  • 1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jungeun34.lee@samsung.com
  • 2Department of pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

We report a case of adult-onset tubulointerstitial nephritis and uveitis syndrome with Fanconi syndrome. A 31-year-woman presented with fever, anorexia, nausea, general weakness and weight loss for two months. Her initial laboratory findings showed anemia, high serum creatinine, hypouricemia, hypophosphatemia, hypokalemia, glucosuria, and proteinuria. She was diagnosed as having acute tubulointerstitial nephritis by renal biopsy. The etiology of tubulointerstitial nephritis was unclear. She was treated with systemic corticosteroid. Six months later and while the patient was still on systemic corticosteroid (Deflazacort 36 mg), bilateral uveitis developed. Renal function was recovered by systemic corticosteroid and mycophenolic acid. But ocular symptoms relapsed twice despite systemic corticosteroid treatment. The ocular symptoms improved after topical ophthalmic steroid drops and injection. Tubulointerstitial nephritis and uveitis syndrome should be considered in the differential diagnosis of the unexplained tubulointerstitial nephritis. And the need of the steroid treatment also should be considered in the case of adult-onset.

Keyword

Tubulointerstitial nephritis; Uveitis; Fanconi syndrome; Steroids

MeSH Terms

Adult
Anemia
Anorexia
Biopsy
Creatinine
Diagnosis, Differential
Fanconi Syndrome
Fever
Humans
Hypokalemia
Hypophosphatemia
Korea
Mycophenolic Acid
Nausea
Nephritis, Interstitial
Proteinuria
Steroids
Uveitis
Weight Loss
Creatinine
Mycophenolic Acid
Nephritis, Interstitial
Steroids
Uveitis
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