J Bacteriol Virol.  2009 Sep;39(3):145-157. 10.4167/jbv.2009.39.3.145.

Activation of Innate Immune System During Viral Infection: Role of Pattern-recognition Receptors (PRRs) in Viral Infection

Affiliations
  • 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea. ykkim@amc.seoul.kr
  • 2Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

Innate immunity and adaptive immunity are two major immune responses against pathogens. Innate immunity is responsible for the immediate immune response to pathogens. Pattern-recognition receptors (PRRs) play an important role in innate immune response. PRRs recognize regular patterns of molecule structure known as pathogen-associated molecular patterns (PAMPs). Among the PRRs, Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and DNA-dependent activator of interferon regulatory factors (DAI) display key roles in response to viral infections. This article reviews how viral infections activate PRR-PAMP signal pathways and how viruses evade immune responses elicited by PRR signal pathways.

Keyword

Innate immunity; Viral infection; Toll-like receptor; RIG-I-like receptor; PAMP
Full Text Links
  • JBV
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr