J Korean Soc Magn Reson Med.
2009 Jun;13(1):40-46.
Quantitative Evaluation of the Corticospinal Tract Segmented by Using Co-registered Functional MRI and Diffusion Tensor Tractography
- Affiliations
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- 1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Korea.
- 2Department of Rehabilitation Science, Taegu University, Korea.
- 3Department of Diagnostic Radiology, College of Medicine, Yeungnam University, Korea.
- 4Department of Physical Medicine and Rehabilitation Medicine, Ulsan University Hospital College of Medicine, Ulsan University, Korea. fnew1@hanmail.net
Abstract
- PURPOSE
The purpose of this study was to investigate the quantitative evaluation of the corticospinal tract (CST) at the multiple levels by using functional MRI (fMRI) co-registered to diffusion tensor tractography (DTT).
MATERIALS AND METHODS
Ten normal subjects without any history of neurological disorder participated in this study. fMRI was performed at 1.5 T MR scanner using hand grasp-release movement paradigm. DTT was performed by using DtiStudio on the basis of fiber assignment continuous tracking algorithm (FACT). The seed region of interest (ROI) was drawn in the area of maximum fMRI activation during the motor task of hand grasp-release movement on a 2-D fractional anisotropy (FA) color map, and the target ROI was drawn in the cortiocospinal portion of anterior lower pons. We have drawn five ROIs for the measurement of FA and apparent diffusion coefficient (ADC) along the corona radiata (CR) down to the medulla.
RESULTS
The contralateral primary sensorimotor cortex (SM1) was mainly found to be activated in all subjects. DTT showed that tracts originated from SM1 and ran to the medulla along the known pathway of the CST. In all subjects, FA values of the CST were higher at the level of the midbrain and posterior limb of internal capsule (PLIC) than the level of others.
CONCLUSION
Our study showed that co-registered fMRI and DTT has elucidated the state of CST on 3-D and analyzed the quantitative values of FA and ADC at the multiple levels. We conclude that co-registered fMRI and DTT may be applied as a useful tool for clarifying and investigating the state of CST in the patients with brain injury.
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