Korean J Obes.  2009 Dec;18(4):167-172.

Two Cases of Polycystic Ovary Syndrome with Metabolic Syndrome Presenting with Hirsutism in Adolescence

Affiliations
  • 1Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Korea. PMJ@paik.ac.kr
  • 2Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine, Korea.

Abstract

Polycystic ovary syndrome (PCOS) is diagnosed by a combination of oligo-anovulation, clinical/biochemical signs of hyperandrogenism, or ultrasound findings consistent with PCOS. It is also associated with metabolic abnormalities, such as dyslipidemia, obesity, and glucose intolerance. In spite of increasing awareness of PCOS in obese adolescents, its clinical diagnosis is often difficult. We report two cases of PCOS presenting with metabolic syndrome and hirsutism. They showed dyslipidemia, insulin resistance and central obesity with waist circumference above 90 percentile and BMI over 95 percentile for their age and sex matched reference value. One patient was diagnosed as having type 2 diabetes. After metformin treatment, there was a significant reduction in body weight and waist circumference but hirsutism was not improved. Careful, long-term observation of these adolescents is needed to evaluate therapeutic outcomes.

Keyword

Polycystic ovary syndrome; Metabolic syndrome; Hirsutism; Obesity; Adolescence

MeSH Terms

Adolescent
Body Weight
Dyslipidemias
Glucose Intolerance
Hirsutism
Humans
Hyperandrogenism
Insulin Resistance
Metformin
Obesity
Obesity, Abdominal
Polycystic Ovary Syndrome
Reference Values
Waist Circumference
Metformin
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