Korean J Gastrointest Endosc.
2009 Jan;38(1):14-19.
Recent Trends in the Eradication Rates of Second-Line Quadruple 14 Therapy for Helicobacter Pylori and the Clinical Factors that Potentially Affect the Treatment Outcome
- Affiliations
-
- 1Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
- 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. dhljohn@snubh.org
Abstract
- BACKGROUND/AIMS
The present study aimed to evaluate the efficacy of second-line quadruple therapy for treating patients with Helicobacter Pylori, and these patients were treated at our hospitals for September, 2003 through April, 2008 in Seongnam, Korea.
METHODS
One hundred and thirty-three patients who failed to respond to the initial PPI-based triple therapy received quadruple therapy, whcih consisted of PPI, bismuth, tetracycline and metronidazole. The patients were divided into two groups. One group was treated for 7 days and the other group was treated for 14 days. Four to six weeks after completing the schedule, a 13C-urea breath test was performed to detect the presence of H. pylori.
RESULTS
The overall intention-to-treat and per-protocol (PP) eradication rates were 75.2% and 81.1%, respectively. The PP eradication rates for the years 2003~2004, 2005, 2006 and 2007~2008 were 76.5%, 82.5%, 91.3% and 75%, respectively. There was no significant difference of the eradication rates according to gender, age and the duration of treatment. Yet the eradication rate of the chronic gastritis group (66.7%) was significantly lower than that of the peptic ulcer group (84.7%) (p=0.030).
CONCLUSIONS
There was no definite downward trend for the eradication rates of second-line quadruple therapy during the 6 year study period. However, the eradication rate in the recent 2 years guaranteed only a 75% cure rate and the quadruple therapy was less effective for the patients with chronic gastritis. Therefore, a novel, more potent novel second-line regimen may be needed for the eradication of H. pylori.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Recent Trends of Helicobacter pylori Eradication Therapy: Focusing on First Line Treatment
- Eradication Rates of First-line and Second-line Therapy for Helicobacter pylori Infection in Gyeongnam Province
- Eradication Rates of Bismuth-based Quadruple Therapy as a Second-line Treatment for Helicobacter pylori Infection
- Recent First Line Eradication Rate of Helicobacter pylori Infection: Single Center Experience
- Recent Trends of Helicobacter pylori Eradication Therapy in Korea
