Electrolyte Blood Press.  2009 Jun;7(1):5-8. 10.5049/EBP.2009.7.1.5.

Acquired Gitelman Syndrome

• Kim YK
• Song HC
• Kim YS
• Choi EJ

• KMID: 1464782
• DOI: http://doi.org/10.5049/EBP.2009.7.1.5

Abstract

Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 gene, which encodes the thiazide - ensitive NaCl cotransporter (NCCT). Acquired Gitelman syndrome has been reported and the majority has been associated with Sjogren's syndrome. The presence of circulating auto - antibodies to NCCT was suggested as a mechanism of acquired Gitelman syndrome. Treatment of acquired Gitelman syndrome was done with supplements of potassium and magnesium and prednisone was effective in some cases. Acquired Gitelman syndrome should be included in the differential diagnosis of renal involvement in patients with autoimmune diseases, especially Sjogren's syndrome.

Keyword

Gitelman syndrome; Sjogren's syndrome; thiazide - ensitive NaCl cotransporter

MeSH Terms

Alkalosis
Antibodies
Autoimmune Diseases
Diagnosis, Differential
Gitelman Syndrome
Humans
Magnesium
Potassium
Prednisone
Sjogren's Syndrome
Antibodies
Magnesium
Potassium
Prednisone